TITER in its most simplist definition. Is a measurement of dilution represented by the ratio of dilution. In this case blood or serum, diluting it with saline.
For an example; diluting 1 part of blood with 32 parts of saline would equal a TITER of 1:32
CAD blood has a higher than normal amount of autoantibodies (IgM). These autoantibodies, when exposed to cool/cold incorrectly attach to Red Blood Cells, thinking the Red Cells are a foreign invader, causing them to clump together (Agglutination), burst and die.
The test to check for this is listed differently by various names depending on the facility/lab. A few are listed below.
Quest – Cold Hemagglutinins
Labcorp Labs- Cold Agglutinin Titer, Quant (Quantitative )
ARUP Labs -Cold Agglutinins
CPL Labs – Cold Agglutinin, Quant (Quantitative )
In the case of testing the TITER of a CAD, the lab techs watch for clumping (Agglutination) and at what ratio of dilution the clumping occurs.
Samples that indicate a Titer of 1:32 or less, are considered nondiagnositic [Negative], but do not necessarily exclude a diagnosis.
This test is always used in conjunction with results from other related tests. Depending on what might be a suspected cause that must be confirmed, or eliminated, when perusing a diagnosis.
Any result above 1:32 is considered “Positive”. But this test is only a piece of other testing that must be done to draw conclusions.
Those with Cold Auto Immune Hemolytic Anemia, and experiencing notable symptoms are usually in the TITER range of over 1:1,024, and could range over 1:500,000. This info can even vary based on the source you look at.
Some sources indicate a Titer of 1:64 and higher is an indicator of Cold Auto Immune Hemolytic Anemia (CAD). But we suspect at lower levels some CADs may be unaware of their conditions until some type of blood test starts showing up as abnormal. Perhaps Agglutination notes on a CBC/RBC, etc?
Those CADs suffering from being really reactive to the cold, and dealing with many physical symptoms, tend to have a higher Titer.
This is one of the tests similar to CBC/RBC that may be difficult to run/result for the more cold reactive CAD. Collection at a satellite facility and shipped to a lab may fail. “Keep It Warm” Techniques may be necessary?
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