A Coombs Test,  is a blood test that detects antibodies that attack Red Blood Cells.  Also Referred to as an Antiglobulin Test.

Antibodies are protiens made by the bodies own immune system, to bind to foreign substances and destroy them.  In a healthy body, to destroy Bacteria and Viruses.  In a CAD, their own Red Cells.

The presence of these antibodies refers to a condition known as Hemolytic AnemiaA point in which the body does not contain adequate Red Blood Cells because they are prematurely destroyed.

Test Results are considered normal if there is no Clumping of Red Blood Cells

There are two tests that are used.

Direct Coombs Test:  More common and checks for antibodies that are attached to the surface of the Red Blood Cells.

Conditions that may cause you to have antibodies on Red Blood Cells:
Autoimmune Hemolytic Anemia
Transfusion Reaction
Mycoplasma Bacterial Infection
Drug related Toxicity
Erythroblastosis Fetalis (infants)

Indirect Coombs Test:
Checks for Antibodies  that are floating around in the bloodstream.  This test is also used to determine if there is the potential of a bad reaction to a Blood Transfusion.

Conditions that may cause you to have Antibodies in your Bloodstream:
Incompatible blood match during a blood transfusion
Autoimmune Hemolytic Anemia
Drug related Toxicity
Erythroblastosis Fetalis (Infants)


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