A Coombs Test,  is a blood test that detects antibodies that attack Red Blood Cells.

Some other related names. Direct Coombs Test, Indirect Coombs Test, Antiglobulin Test, Direct Antiglobulin Test, or DAT.

Antibodies are proteins made by the bodies own immune system, to bind to foreign substances and destroy them.  In a healthy body the antibodies are used to destroy foreign Bacteria and Viruses.  In a CAD, they are attacking the bodies own Red Cells.

The presence of these antibodies refers to a condition known as Hemolytic Anemia.   The point in which the body does not contain adequate Red Blood Cells because they are prematurely destroyed.

Test Results are considered normal if there is no Clumping of Red Blood Cells

There are two tests that are used.

Direct Coombs Test:  More common and checks for antibodies that are attached to the surface of the Red Blood Cells.

Conditions that may cause you to have antibodies to Red Blood Cells:
Autoimmune Hemolytic Anemia
Transfusion Reaction
Mycoplasma Bacterial Infection
Drug related Toxicity
Erythroblastosis Fetalis (infants)

Indirect Coombs Test:
Checks for Antibodies  that are floating around in the bloodstream.  This test is also used to determine if there is the potential of a bad reaction to a Blood Transfusion.

Conditions that may cause you to have Antibodies in your Bloodstream:
Incompatible blood match during a blood transfusion
Autoimmune Hemolytic Anemia
Drug related Toxicity
Erythroblastosis Fetalis (Infants)


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